Vehicle comparison
Audi A6 vs Mercedes-Benz E-Class (E350)
Side-by-side fuel and ownership cost comparison. Estimates use 12,000 mi/year at average US gas prices.
- Updated for 2026
- EPA-style MPG
- US avg fuel prices
- US units
- Transparent assumptions
Lowest running cost
Audi A6 wins on fuel cost
At 12,000 miles per year, the Audi A6 costs about $1822 per year, roughly $0 less than the Mercedes-Benz E-Class (E350). Over 5 years, that's about $0 in fuel savings.
Spec & cost comparison
MPG/MPGe figures are estimates based on typical recent model years.
| Spec | Audi A6 | Mercedes-Benz E-Class (E350) |
|---|---|---|
| Type | SEDAN | SEDAN |
| Fuel | Premium gas | Premium gas |
| City MPG/MPGe | 24 | 23 |
| Highway MPG/MPGe | 33 | 32 |
| Combined MPG/MPGe | 27 | 27 |
| Tank / Battery | 19.3 gal | 17.4 gal |
| Energy cost | $4.10/gal | $4.10/gal |
| Cost per mile | $0.152 | $0.152 |
Annual cost at 8k / 12k / 15k miles
Estimated yearly fuel spend at common US mileage levels.
| Miles/year | Audi A6 | Mercedes-Benz E-Class (E350) | Difference |
|---|---|---|---|
| 8,000 | $1215/yr · $101/mo | $1215/yr · $101/mo | $0 (Tie) |
| 12,000 | $1822/yr · $152/mo | $1822/yr · $152/mo | $0 (Tie) |
| 15,000 | $2278/yr · $190/mo | $2278/yr · $190/mo | $0 (Tie) |
Estimates only. Real costs depend on driving style, terrain, local gas/electricity prices and weather.
Which one is best for…
Best for commuting
Audi A6
Highest combined MPG/MPGe and lowest cost per mile means cheaper daily driving.
See Audi A6Best for road trips
Audi A6
Better highway efficiency, larger tank/battery and longer range between stops.
See Audi A6Best for families
Audi A6
SUVs, minivans and three-row vehicles win on space and child-seat flexibility.
See Audi A6Best for lowest running cost
Audi A6
Cheaper energy use and lower cost per mile at every common mileage tier.
See Audi A6How we compare these vehicles
- Annual mileage
- Modeled at 12,000 mi/yr unless a scenario specifies otherwise.
- Cost per mile
- $/gal ÷ MPG, or $/kWh ÷ (MPGe ÷ 33.7) for EVs.
- EV vs gas
- Compared at average US gas and residential electricity prices — fast-charging can be 2–3× higher.
- Maintenance
- Fuel cost only — EVs typically save another $400–$1,000/yr in service and brake wear.
Sources & assumptions
- EPA fuel economy data — City / highway / combined MPG and MPGe baselines.
- U.S. Department of Energy (fueleconomy.gov) — Vehicle efficiency and EV range references.
- AAA gas price trends — Recent national and regional retail fuel averages.
- EIA electricity rates — Average residential per-kWh prices used for EV charging.
We summarize publicly available data — no scraping, no external API calls. Figures are calibrated periodically; use the calculators above for your exact inputs.
Frequently asked questions
Which is cheaper to drive, the Audi A6 or Mercedes-Benz E-Class (E350)?
At 12,000 miles per year, the Audi A6 costs about $1822 per year vs $1822 for the Mercedes-Benz E-Class (E350) — roughly $0 less per year.
What's the MPG difference between the Audi A6 and Mercedes-Benz E-Class (E350)?
The Audi A6 is rated around 27 combined MPG versus 27 MPG for the Mercedes-Benz E-Class (E350). Highway figures are 33 vs 32.
How much will I spend on fuel over 5 years?
Driving 12,000 miles a year for five years, expect about $9111 for the Audi A6 and $9111 for the Mercedes-Benz E-Class (E350), a difference of roughly $0.
Is the Audi A6 or Mercedes-Benz E-Class (E350) better for commuting?
For pure cost per mile, the Audi A6 wins. EVs charged at home typically deliver the lowest commuting cost, followed by hybrids and efficient compacts.
Which one is better for road trips?
Audi A6 is generally the better road-trip choice — gas and hybrid vehicles win on long highway routes thanks to faster refueling, while EVs work best when charging stops fit your route.
Are these fuel cost numbers accurate for my driving?
They're estimates based on EPA-style combined MPG and average US gas prices. Real-world cost depends on local fuel prices, driving style, terrain, weather and how much city vs highway driving you do.