DriveCosts

Road trip cost

How Much Does It Cost to Drive From Des Moines to St. Louis?

The drive from Des Moines, IA to St. Louis, MO covers about 322 miles and takes around 5 hr 12 min — a comfortable day trip. Plan one fuel stop and a meal break and you'll arrive without overspending on gas.

Medium
  • Updated for 2026
  • US avg fuel prices
  • EPA-style MPG
  • EV rates vary by state
  • US units
Distance

322 mi

Driving time

5 hr 12 min

Fuel stops

0

EV charges

1

Route overview322 mi

Key takeaway

Plan on about $40 in gas one-way in a 28 MPG sedan, with 0 fuel stops and roughly 5 hr 12 min behind the wheel.

Drive intensity

Medium

Doable in a single day.

Estimate your trip cost

Pre-filled with the Des Moines → St. Louis distance.

miles
mpg
$/gal

Estimated Trip Cost

$0.00

Per Person

$0.00

Gallons

0.00gal

Total miles: 322 (one way).

How we estimate this trip

Distance
Great-circle distance between city centers × 1.18 road factor, rounded to whole miles.
Fuel cost formula
(miles ÷ MPG) × price per gallon, computed one-way unless noted.
Gas price assumption
Recent US average retail regular gas (AAA-style baseline).
EV charging assumption
Combined MPGe with average US residential electricity rate.
Tolls & weather
Not included — add manually for I-95, I-90 and mountain routes.
Driving time
Estimated at typical highway average speeds; excludes long breaks.

Sources & assumptions

  • EPA fuel economy data — City / highway / combined MPG and MPGe baselines.
  • U.S. Department of Energy (fueleconomy.gov) — Vehicle efficiency and EV range references.
  • AAA gas price trends — Recent national and regional retail fuel averages.
  • EIA electricity rates — Average residential per-kWh prices used for EV charging.

We summarize publicly available data — no scraping, no external API calls. Figures are calibrated periodically; use the calculators above for your exact inputs.

Fuel cost by vehicle type

Estimated one-way fuel cost at $3.45/gal (US average). Adjust for your local price.

Compact car· 35 MPG · 9.2 gal$31.74
Sedan· 28 MPG · 11.5 gal$39.68
SUV· 22 MPG · 14.6 gal$50.50
Pickup truck· 18 MPG · 17.9 gal$61.72

Cost at different gas prices

Assuming a 28 MPG sedan over the 322-mile route.

Gas at $3.15/gal

$36.23

one way · ~11.5 gal

Gas at $3.45/gal

$39.68

one way · ~11.5 gal

Gas at $3.85/gal

$44.27

one way · ~11.5 gal

Fuel & charging stops

No fill-up needed

At ~322 miles, a full tank in a typical sedan (~350-mile range) covers this drive end-to-end. Top up before you leave and you're set.

1 DC fast-charge for most EVs

Assuming a realistic 230-mile highway range, plan 1 DC fast-charging stop. Tesla Superchargers and Electrify America have strong coverage on most US corridors.

Route personality

Standard interstate drive

Midwest driving context

  • Flat, straight interstates (I-70, I-80, I-90) reward steady speeds and deliver near-EPA highway MPG.
  • Winter snow and lake-effect storms can close stretches of road from December through March.

City insights

Des Moines, IA

  • Government and event-day closures around downtown Des Moines can reroute traffic.

St. Louis, MO

  • St. Louis traffic is heaviest 7–9 am and 4–7 pm — time your arrival around it.

Best stops along the way

  • Pick a sit-down meal stop around the 2.5-hour mark to reset focus and avoid drive-thru fatigue.
  • Truck-stop plazas (Pilot, Love's, TA) reliably have fuel, food and clean restrooms every 60–90 miles.

Seasonal notes

Winter

Snow, ice and chain-control zones from late November through March — carry an emergency kit.

Spring–Summer

Midwest construction season is March–October — expect single-lane closures on I-70, I-80 and I-90.

Recommendations for this route

  • Run tires at the door-jamb PSI and pre-cool the cabin with AC on low — both add 1–3 MPG.

Is it cheaper to fly or drive?

Driving is almost always cheaper here — short flights cost more than fuel once you factor in airport parking, bags and a rental car.

A one-way drive uses about $40 in gas (28 MPG, $3.45/gal). A typical short domestic flight costs $80–$220 per person plus $30–$60/day for airport parking and any baggage fees.

Weather & best time

Spring and fall offer the most comfortable driving conditions and lighter holiday traffic.

  • • Mostly straightforward weather year-round, though summer heat and winter rain can still slow traffic.

Tolls

Mostly toll-free — you can drive this without a transponder.

Best vehicle

A mid-size sedan or hybrid is the sweet spot — comfortable for the distance with strong MPG.

Driving difficulty

Medium · 5 hr 12 min

Moderate — plan at least two 15-minute breaks and swap drivers if possible.

Doable in a single day

Most drivers complete this route in a single day. Leave early to avoid arriving tired in evening traffic.

About the drive from Des Moines to St. Louis

This 322-mile route between Des Moines, IA and St. Louis, MO is a popular drive in the region. Expect roughly 5 hr 12 min behind the wheel under normal traffic conditions.

Fuel-saving tips

  • Keep your speed near 65 mph — fuel economy drops sharply above 70.
  • Fill up before mountain or desert stretches; remote stations charge a premium.
  • Use GasBuddy or AAA to spot cheap stations along your route before you leave.

Frequently asked questions

How long does it take to drive from Des Moines to St. Louis?

The drive is about 322 miles and takes roughly 5 hr 12 min under normal traffic. Add buffer for stops, construction, and rush hour around either city.

How much gas does the trip use?

In a 28 MPG sedan, expect about 11.5 gallons one way. A 22 MPG SUV would use roughly 14.6 gallons.

What's the typical fuel cost?

At the US average of $3.45/gal, a 28 MPG vehicle costs about $39.68 one way. Round trip roughly doubles that. Use the calculator above for your exact MPG and local gas price.

How many fuel or charging stops will I need?

A typical gas sedan needs about 0 fuel stops one way. A modern EV with ~230 miles of highway range needs about 1 DC fast-charge.

Is it cheaper to drive or fly from Des Moines to St. Louis?

Driving is almost always cheaper here — short flights cost more than fuel once you factor in airport parking, bags and a rental car.

What's the best time of year to drive this route?

Spring and fall offer the most comfortable driving conditions and lighter holiday traffic.

Best vehicles for this route

Estimated 322-mile fuel cost for each pick at average US prices. Tap any vehicle for a full cost breakdown.

Cheapest to drive

Toyota Prius

57 MPG · hybrid

~$19

est. one-way fuel cost

See full breakdown

Best EV

Lucid Air

134 MPGe · ev

~$13

est. one-way charging cost

See full breakdown

Best sedan

Hyundai Elantra

37 MPG · sedan

~$30

est. one-way fuel cost

See full breakdown

Best SUV for comfort

Nissan Rogue

33 MPG · suv

~$34

est. one-way fuel cost

See full breakdown

Best truck for cargo

Ford Maverick

26 MPG · truck

~$43

est. one-way fuel cost

See full breakdown

Related routes

More routes like Des Moines to St. Louis

Reverse drives, connecting routes and regional alternatives — each with distance and driving cost at current US gas prices.

Reverse drive

St. Louis to Des Moines driving cost

322 mi · 5.2 h

Related road trips

More routes from Des Moines, St. Louis, and the surrounding region.

St. Louis → Des Moines

~322 mi · 5 hr 12 min

See cost

Chicago → St. Louis

~300 mi · 4 hr 30 min

See cost

Nashville → St. Louis

~299 mi · 4 hr 48 min

See cost

Little Rock → St. Louis

~345 mi · 5 hr 36 min

See cost

Topeka → St. Louis

~350 mi · 5 hr 36 min

See cost

Des Moines → Springfield

~358 mi · 5 hr 48 min

See cost

Louisville → St. Louis

~285 mi · 4 hr 36 min

See cost

Memphis → St. Louis

~284 mi · 4 hr 36 min

See cost

Cincinnati → St. Louis

~363 mi · 5 hr 54 min

See cost

Des Moines → Madison

~281 mi · 4 hr 30 min

See cost
More IA road trips →More MO road trips →Cheapest road trips →Weekend road trips →Long-distance drives →EV-friendly routes →Browse all routes →Custom trip calculator →