About the drive from St. Louis to Miami
This 1254-mile route between St. Louis, MO and Miami, FL is a popular drive in the region. Expect roughly 20 hr 12 min behind the wheel under normal traffic conditions.
Fuel-saving tips
- Keep your speed near 65 mph — fuel economy drops sharply above 70.
- Fill up before mountain or desert stretches; remote stations charge a premium.
- Use GasBuddy or AAA to spot cheap stations along your route before you leave.
- Plan to avoid rush hour in both cities — stop-and-go traffic can cut highway MPG by 20%.