About the drive from San Francisco to Amarillo
This 1363-mile route between San Francisco, CA and Amarillo, TX is a popular drive in the region. Expect roughly 22 hr behind the wheel under normal traffic conditions.
Fuel-saving tips
- Keep your speed near 65 mph — fuel economy drops sharply above 70.
- Fill up before mountain or desert stretches; remote stations charge a premium.
- Use GasBuddy or AAA to spot cheap stations along your route before you leave.