About the drive from Pittsburgh to Indianapolis
This 389-mile route between Pittsburgh, PA and Indianapolis, IN is a popular drive in the region. Expect roughly 6 hr 18 min behind the wheel under normal traffic conditions.
Fuel-saving tips
- Keep your speed near 65 mph — fuel economy drops sharply above 70.
- Fill up before mountain or desert stretches; remote stations charge a premium.
- Use GasBuddy or AAA to spot cheap stations along your route before you leave.
- Plan to avoid rush hour in both cities — stop-and-go traffic can cut highway MPG by 20%.