About the drive from Myrtle Beach to Louisville
This 586-mile route between Myrtle Beach, SC and Louisville, KY is a popular drive in the region. Expect roughly 9 hr 30 min behind the wheel under normal traffic conditions.
Fuel-saving tips
- Keep your speed near 65 mph — fuel economy drops sharply above 70.
- Fill up before mountain or desert stretches; remote stations charge a premium.
- Use GasBuddy or AAA to spot cheap stations along your route before you leave.