Road trip cost
The drive from Ann Arbor, MI to Louisville, KY covers about 352 miles and takes around 5 hr 42 min — a comfortable day trip. Plan one fuel stop and a meal break and you'll arrive without overspending on gas.
352 mi
5 hr 42 min
1
1
1 suggested fuel stop
Key takeaway
Drive intensity
Doable in a single day.
Pre-filled with the Ann Arbor → Louisville distance.
Estimated Trip Cost
$0.00
Per Person
$0.00
Gallons
0.00gal
Total miles: 352 (one way).
We summarize publicly available data — no scraping, no external API calls. Figures are calibrated periodically; use the calculators above for your exact inputs.
Estimated one-way fuel cost at $3.45/gal (US average). Adjust for your local price.
Assuming a 28 MPG sedan over the 352-mile route.
$39.60
one way · ~12.6 gal
$43.37
one way · ~12.6 gal
$48.40
one way · ~12.6 gal
A typical 28 MPG sedan with a 12.5-gallon tank covers about 350 miles per fill-up. Plan 1 stop along the way and fuel up before any remote stretches.
Assuming a realistic 230-mile highway range, plan 1 DC fast-charging stop. Tesla Superchargers and Electrify America have strong coverage on most US corridors.
Midpoint
Cincinnati, OH
Roughly halfway between Ann Arbor and Louisville. A natural place to fuel up, grab a meal, swap drivers, or stop overnight on longer drives.
Route personality
Standard interstate driveAnn Arbor, MI
Louisville, KY
Winter
Snow, ice and chain-control zones from late November through March — carry an emergency kit.
For one or two people, driving usually wins on cost. Solo travelers with no luggage may find a budget flight cheaper once you add parking and meals.
A one-way drive uses about $43 in gas (28 MPG, $3.45/gal). A typical short domestic flight costs $80–$220 per person plus $30–$60/day for airport parking and any baggage fees.
Spring and fall offer the most comfortable driving conditions and lighter holiday traffic.
Mostly toll-free — you can drive this without a transponder.
A mid-size sedan or hybrid is the sweet spot — comfortable for the distance with strong MPG.
Moderate — plan at least two 15-minute breaks and swap drivers if possible.
Most drivers complete this route in a single day. Leave early to avoid arriving tired in evening traffic.
This 352-mile route between Ann Arbor, MI and Louisville, KY is a popular drive in the region. Expect roughly 5 hr 42 min behind the wheel under normal traffic conditions.
The drive is about 352 miles and takes roughly 5 hr 42 min under normal traffic. Add buffer for stops, construction, and rush hour around either city.
In a 28 MPG sedan, expect about 12.6 gallons one way. A 22 MPG SUV would use roughly 16.0 gallons.
At the US average of $3.45/gal, a 28 MPG vehicle costs about $43.37 one way. Round trip roughly doubles that. Use the calculator above for your exact MPG and local gas price.
A typical gas sedan needs about 1 fuel stop one way. A modern EV with ~230 miles of highway range needs about 1 DC fast-charge.
For one or two people, driving usually wins on cost. Solo travelers with no luggage may find a budget flight cheaper once you add parking and meals.
Spring and fall offer the most comfortable driving conditions and lighter holiday traffic.
Cincinnati, OH is roughly halfway and makes a natural fuel, food, or overnight break.
Estimated 352-mile fuel cost for each pick at average US prices. Tap any vehicle for a full cost breakdown.
Cheapest to drive
57 MPG · hybrid
~$21
est. one-way fuel cost
See full breakdownBest EV
134 MPGe · ev
~$14
est. one-way charging cost
See full breakdownBest sedan
37 MPG · sedan
~$33
est. one-way fuel cost
See full breakdownBest SUV for comfort
33 MPG · suv
~$37
est. one-way fuel cost
See full breakdownBest truck for cargo
26 MPG · truck
~$47
est. one-way fuel cost
See full breakdownRelated routes
Reverse drives, connecting routes and regional alternatives — each with distance and driving cost at current US gas prices.
Reverse drive
Louisville to Ann Arbor driving cost
352 mi · 5.7 h
Other road trip cost estimates that start in Ann Arbor, MI.
Other routes with Louisville, KY as the destination.
Same-state and neighboring-state drives with similar driving cost.
Longer connected routes leaving Louisville, KY — great for multi-day road trip planning.
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